In contrast, elderly patients are more likely to experience unwanted side effects (such as severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and organ dysfunction (such as kidney or liver failure), which may necessitate caution and a dose reduction for patients taking this medication.
Alprazolam has been observed to cause aggression-like behavior in certain patients after prolonged usage (reviewed by), however in patients with dementia, alprazolam has been shown to reduce agitation and symptoms on the clinical global impression scale, resulting in a considerable reduction in symptoms.
Some of the more dangerous side effects can be avoided if you follow these precautions. A younger adult who takes alprazolam will digest the medicine far more quickly than an elderly person who takes the same medication. Alprazolam reaches its greatest concentration in the bloodstream of a younger person during the first two hours after consuming it.
Verster et al. have established the acute effects of 1 mg alprazolam, which decreases psychomotor performance as well as particular cognitive abilities essential for daily tasks such as driving ability, according to their findings.
Benzodiazepines with a short half-life, such as oxazepam, alprazolam, and triazolam, are often advised for older persons because they do not build in the bloodstream, are promptly removed from circulation, and allow for more dosing flexibility.
It has been shown that the use of benzodiazepines in older persons can impair cognition, mobility, and driving abilities, and can increase the risk of falling. A previous study also discovered a link between benzodiazepine usage in elderly adults and an increased risk of Alzheimer’s disease, according to the researchers.
Oxazepam and lorazepam (and maybe alprazolam) are the benzodiazepines of choice for older patients because of their shorter half-lives and the lack of (or quick disappearance of) active metabolites generated by their method of metabolism, respectively.
Nonbenzodiazepines, such as zolpidem, eszopiclone, zaleplon, and ramelteon, are safer and more tolerated in the elderly than tricyclic antidepressants, antihistamines, and benzodiazepines, according to the American Academy of Neurology. Pharmacotherapy, on the other hand, should only be indicated once sleep hygiene has been addressed.
However, prescription sedative medicines such as benzodiazepines, which are used to treat anxiety and insomnia, are associated with severe dangers, particularly in older persons. Many individuals in their 60s, 70s, and 80s take anti-anxiety drugs – such as Xanax, Valium, and Ativan – and do so for an extended period of time, often for years.
Buspirone is an anti-anxiety medication that has been demonstrated to be beneficial in the treatment of elderly patients. However, because they have the potential to induce memory impairment, unsteadiness, and falls in older persons, benzodiazepines, another anti-anxiety medication, should only be taken with caution.
The majority of people who use this medicine do not have any substantial adverse effects. You should contact your doctor immediately if any of the following unlikely but significant adverse effects occur: altered mental/emotional state (such as hallucinations or suicidal thoughts), slurred speech or difficulty speaking; lack of coordination; difficulties walking; memory issues
Tricyclic antidepressants, particularly amitriptyline and dothiepin16, are well-known for posing a substantial risk of mortality in the event of an overdose. As a result, these medications should be avoided in older adults who are taking medicine without supervision and who are at risk of taking an overdose.
Both medicines are included on the Beers’ List of prohibited substances (drugs that may be inappropriate in older adults). When using Ativan or Xanax, older persons have higher sensitivity to benzodiazepines, and there is an increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle accidents in older adults.
While there are some similarities, there are some significant variations as well. For example, while Xanax is more quickly effective, it has a shorter duration of action (4 to 6 hours) when compared to Lorazepam’s 8 hours. With Xanax, sedative and performance-impairing effects may manifest themselves sooner, but they diminish more quickly than with lorazepam.
While using alprazolam, you should avoid consuming alcoholic beverages and utilizing illicit substances. They may reduce the advantages of the drug (for example, by making your illness worse) while increasing the unpleasant effects (for example, sedation). The use of alcoholic beverages increases the likelihood of an unintentional overdose with drugs such as alprazolam.
Despite the fact that alprazolam, the primary component in Xanax, is likely to make you feel fatigued, it is not a recommended medicine to use for insomnia treatment. Not only does it shorten the amount of time you spend in deep sleep, leading you to perform poorly the next day, but it also has the potential to become addicted in the long run.
Conclusion: There is a statistically significant relationship between the level of blood pressure and anxiety in hypertensive ED patients. Alprazolam is equally effective as captopril in decreasing blood pressure in individuals with erectile dysfunction who had an initial SBP greater than 160 mmHg.