According to the study, popular Prozac-like pills known as SSRIs — selective serotonin reuptake inhibitors — and other antidepressants are associated with a twofold increase in the odds of developing some form of dementia , including Alzheimer’s.
Sertraline is generally well tolerated in elderly patients with major depressive disorder and lacks the marked anticholinergic effects that characterise the adverse event profiles of tricyclic antidepressants (TCAs).
SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline.
Uncommon (But Serious) Side Effects Hallucinations. Impulsiveness. Memory loss . Symptoms associated with psychosis, major depression, or mania.
Avoid alcohol completely while you take Zoloft . Even a single drink can interact with your medication and cause unwanted side effects. The combination of alcohol and Zoloft can cause side effects, and drinking alcohol can make your depression worse.
Options include citalopram ( Celexa ), fluoxetine ( Prozac ), nortriptyline (Pamelor), paroxetine ( Paxil ), and sertraline ( Zoloft ). Side effects of these medicines can include drowsiness, dry mouth, constipation, and anxiety.
When it comes to antidepressants for seniors, most experts recommend SSRIs or selective norepinephrine reuptake inhibitors ( SNRIs ), which help increase the brain chemicals serotonin and norepinephrine. These drugs tend to have fewer serious side effects and drug interactions than older antidepressants on the market.
Buspirone is an anti-anxiety drug that has been shown to be effective for older adults. Benzodiazepines , another anti-anxiety drug, are effective but should be prescribed carefully to older adults because of risk of memory impairment, unsteadiness, and falls.
A usual sertraline dosage is 50mg to 100mg per day, which is commonly prescribed to adults as a treatment for depression and some anxiety disorders. The maximum dose of sertraline is 200mg per day, which is usually reached after several weeks or months of treatment at a lower dose.
Researchers found treatment with the drug Zoloft , which is commonly prescribed to treat depression, obsessive-compulsive disorder, and panic disorder, significantly improved the quality of life for Alzheimer’s patients with depression and reduced behavioral disturbances such as agitation, aggression and anxiety.
New research links certain medications to dementia risk amitriptyline , paroxetine, and bupropion (most commonly taken for depression) oxybutynin and tolterodine (taken for an overactive bladder) diphenhydramine (a common antihistamine, as found in Benadryl ).
AVOID products that contain the antihistamines diphenhydramine (Benadryl) and chlorpheniramine (AllerChlor, Chlor-Trimeton). These medications are often included in OTC remedies for coughs, colds, and allergies. AVOID OTC sleep products, like Tylenol PM, which contain antihistamines such as diphenhydramine.
Brain zaps are electrical shock sensations in the brain . They can happen in a person who is decreasing or stopping their use of certain medications, particularly antidepressants. Brain zaps are not harmful and will not damage the brain . However, they can be bothersome, disorienting, and disruptive to sleep.
2 SSRIs work by blocking the reabsorption of serotonin into neurons in the brain . Serotonin is a chemical neurotransmitter, which transmits electrical impulses from one neuron to the next.
A lack of oxygen to the brain can affect short – term memory . Alcohol and drug abuse, concussions and other trauma to the head can impact short – term memory . Medical conditions such as seizures, epilepsy, heart bypass surgery and depression can also impact short – term memory .