The traditional memory medications, cholinesterase inhibitors such as Aricept , may make this form of dementia worse and are usually not recommended.
Donepezil can cause tiredness, dizziness, drowsiness, confusion and muscle cramps.
Terminating treatment, especially abruptly , is not without consequences for the patient. It has been reported that intense hallucinations can occur after sudden donepezil withdrawal . One published study has suggested that discontinuation of treatment with donepezil may bring withdrawal symptoms .
Aricept (donepezil) improves the function of nerve cells in the brain . It works by preventing the breakdown of a chemical called acetylcholine (ah SEET il KOE leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.
New research links certain medications to dementia risk amitriptyline , paroxetine, and bupropion (most commonly taken for depression) oxybutynin and tolterodine (taken for an overactive bladder) diphenhydramine (a common antihistamine, as found in Benadryl ).
“The development of this list has sometimes been taken the wrong way by family care partners. Don’t say ‘but you don’t look or sound like you have dementia ‘. Don’t tell us ‘ we are wrong’. Don’t argue with us or correct trivial things. Don’t say ‘remember when…’.
Aricept is the most widely prescribed medication in a class of Alzheimer’s drugs known as cholinesterase inhibitors. Close to 50% of people stop taking it within a year because of side effects such as weight loss, agitation, and fainting, or because they no longer see any improvements in their mental abilities.
The researchers discovered that those who had an impaired sense of smell in the left nostril had early-stage Alzheimer’s . They noted that the participants needed to be an average of 10 centimeters closer to the peanut butter container in order to smell it from their left nostril compared to their right nostril.
Nausea , vomiting , diarrhea, loss of appetite/weight loss, dizziness, drowsiness, weakness , trouble sleeping, shakiness (tremor), or muscle cramps may occur as your body adjusts to the drug. These effects usually last 1-3 weeks and then lessen.
Donepezil ( Aricept ) and rivastigmine (Exelon), medications used to treat dementia in Alzheimer’s patients, affect sleep quality — specifically, the quality and amount of dreaming. Interestingly, researchers found that donepezil taken at night increased nightmares , but a morning dose had no such effect.
The manufacturer reports that 5% of patients taking donepezil have developed agitation, although only 1% with physical aggression (personal communica- tion). We suggest the need for close specialist monitoring of this recently licensed drug.
Galantamine (Razadyne) Galantamine works just as well as donepezil and rivastigmine at controlling symptoms of AD.
It typically peaks in the middle stages of Alzheimer’s, and then diminishes as the disease progresses. Scientists don’t completely understand why sleep disturbances occur with Alzheimer’s disease and dementia .
ROLE OF THE PHARMACIST According to the 2019-2020 Pharmacy Times® OTC national survey, Prevagen is the number-1 pharmacist – recommended memory support brand among pharmacists who recommend memory support products.
Researchers developed the diet by looking at the Mediterranean and DASH diets, then focusing on the foods with the most compelling findings in dementia prevention. Vegetables , especially leafy greens , rose to the top. In general, fruit didn’t, though berries made the list.