Quick Answer: What Rate Do Elderly Metabolize Medications?

Quick Answer: What Rate Do Elderly Metabolize Medications?

In the elderly, hepatic drug clearance of some drugs can be reduced by up to 30% and CYP-mediated phase I reactions are more likely to be impaired than phase II metabolism, which is relatively preserved in the elderly.

Do older people metabolize drugs faster?

Ageing is associated with a reduction in first-pass metabolism. This is probably due to a reduction in liver mass and blood flow [52]. As a result, the bioavailability of drugs undergoing extensive first-pass metabolism such as propranolol and labetalol can be significantly increased [53–55].

How does drug metabolism change with age?

Generally, older age is associated with increased blood concentrations of drugs and altered metabolism, reduced effectiveness, and increased risk of adverse reactions for many medications (2). Therefore, age-related changes in drug metabolism and elimination have much broader implications for disease susceptibility.

How does age affect drug dosing?

The decline in the rate of drug metabolism with advancing age is less marked. In addition, the volume of distribution and the oral bioavailability of drugs may be changed in the elderly compared with younger individuals.

Are the elderly less sensitive to drugs?

Decreased Blood-Pressure Maintaining Ability: Because older adults are less able to compensate for some of the effects of drugs, there is yet another reason why they are more vulnerable to adverse effects of drugs and more sensitive to the intended effects.

Which percentage reduction in total body water occurs in older adults?

The most important principle in the elderly surgical patient is to maintain normal intravascular volume. Total body water decreases with age. In a younger man near his ideal body weight, total body water composes 60% to 65% of his body mass. By age 80 years, this contribution is reduced to 50%.

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What causes the rate of absorption of a medication to be affected in the elderly?

In the elderly there is a reduction in gastric pH which, in the case of some drugs, affects the solubility and thus will influence the rate of absorption. Furthermore, there is a reduction in intestinal blood flow, which would tend to delay or reduce drug absorption.

Why elderly thin people may store large amounts of fat soluble drugs?

Older people, even when thin, may store large amounts of fat-soluble drugs because the proportion of body fat increases with age.

Which factors alter drug metabolism in older adults?

Aging results in a number of significant changes in the human liver including reductions in liver blood flow, size, drug-metabolizing enzyme content, and pseudocapillarization. Drug metabolism is also influenced by comorbid disease, frailty, concomitant medicines, and (epi)genetics.

What age group metabolizes drugs more rapidly?

to older children, and therefore may require higher doses of water-soluble drugs than those over age 2. Metabolism: As children mature, liver enzymes are able to effectively metabolize most drugs, because the BMR in children is higher than in adults, drugs are metabolized more quickly.

How age can affect the metabolism and excretion of medications?

As age increases, the functions of tissues and organs in the body gradually decline. Due to this decline in organ function, drug absorption, distribution, metabolism and excretion (ADME processes) in elderly people are worse than those of young people.

How medications affect the elderly?

Common side effects of medicines in older adults can be dizziness and falls, weight loss or weight gain, and changes in memory or our ability to think and process information. These, in turn, can cause older adults to get hurt and may ultimately lessen their ability to function in day-to-day life.

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What factors affect drug absorption metabolism and elimination?

There are four factors that will influence the pharmacokinetic drugs test: water-solubility; fat-soluble; dissociation degree and molecular weight. Pharmacokinetic is a quantitative study of drugs in the body absorption, distribution, metabolism and excretion of the law.

What is the most common medication problem in the elderly?

Warfarin is one of the most common causes of medication-related hospitalizations in older adults. To reduce the risk of serious problems, one may need to apply extra care in monitoring warfarin effect (via the prothrombin blood test) and extra care in checking for interactions when a new drug is prescribed.

Why are drugs metabolized?

The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there. The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.

For what reasons are elderly considered sensitive?

Elderly individuals have the potential to exhibit sensitivity to a broad range of substances. This is due to internal biological changes associated with the aging body, present state of health, and genetic predisposition.

Alice Sparrow

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