Gastrointestinal side effects such as ulcers and bleeding are the most prevalent and life-threatening problems associated with NSAIDs. Specifically in the elderly, NSAIDs have become a leading cause of hospitalization and may increase the risk of death from ulceration more than 4-fold.
Avoid NSAIDs like ibuprofen and naproxen Older adults should be very careful with NSAIDs. Their side effects are especially likely to cause harm as people get older. Serious and fatal side effects from NSAIDs include: Risk of bleeding in the stomach, small bowel, or colon.
Stop taking ibuprofen and get medical help right away if you notice any of these rare but serious side effects: black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body,
Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ibuprofen in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving ibuprofen.
NSAID use increases the risk of GI bleeding in the elderly four folds . The mechanism underlying NSAIDs induced GI adverse effects lies in the fact that these medications inhibit prostaglandin synthesis, causing weakening of the protective GI mucosal barrier, predisposing one to bleeding.
If you’re over 65 ibuprofen can make you more likely to get stomach ulcers. Your doctor will prescribe you a medicine to protect your stomach if you’re taking ibuprofen for a long term condition.
NSAIDs, like other drugs, have the risk of side effects. Older people and those with some chronic illnesses may have increased risk for side effects from NSAIDs. These include:
You shouldn’t take ibuprofen if you: have a history of a strong, unpleasant reaction (hypersensitivity) to aspirin or other NSAIDs. have a current or recent stomach ulcer, or you have had one in the past. have severe heart failure.
Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: hives. facial swelling. temporarily relieves minor aches and pains due to:
How serious is this risk? A: Ibuprofen, such as Advil, Motrin or Ibuprofen, can cause marked worsening of existing hypertension (high blood pressure) or development of new high blood pressure. It can also cause damage to the kidneys (nephrotoxicity), worsening of heart failure, and even heart attack or stroke.
Side effects of NSAIDs
Although over-the- counter dosing of NSAIDs has a relatively safe profile , elderly patients are at higher risk of NSAID-related adverse advents, especially potentially fatal gastrointestinal (GI), cardiovascular (CV) and cerebrovascular morbidities .
Increased Sensitivity to Many Drugs: The problems of decreased body size, altered body composition (more fat, less water), and decreased liver and kidney function cause many drugs to accumulate in older people’s bodies at dangerously higher levels and for longer times than in younger people.
A broad range of renal side effects has been ascribed to NSAIDs, of which acute renal impairment is the most common in the elderly. Although most NSAIDs have been reported to cause hepatotoxicity, serious abnormalities of liver function are rare and are largely unpredictable.
The evidence for which NSAIDs are less risky is limited. One retrospective cohort study found that celecoxib, as compared to nonselective NSAIDs (ibuprofen, diclofenac, naproxen) carried the least risk of hospitalization for GI bleeding among elderly persons.