The most commonly reported definition of polypharmacy was the numerical definition of five or more medications daily (n = 51, 46.4% of articles), with definitions ranging from two or more to 11 or more medicines.
Possible symptoms of polypharmacy include: Loss of appetite. Falls. Confusion. Weakness. Tremors. Dizziness . Anxiety. Depression.
How Physicians Can Prevent or Better Manage Polypharmacy Be militant about medication reconciliation. Ask patients if they are being treated by other physicians and providers. Verify that there is an actual indication for every medication being taken. Assess deprescribing opportunities at every visit or care transition. Involve a pharmacist.
Polypharmacy is common among elderly persons because of the need to treat the various disease states that develop with age. Although the deprescribing of unnecessary medications is a way of limiting polypharmacy , the underprescribing of effective therapies in older patients is a concern.
Unfortunately, there are many negative consequences associated with polypharmacy . , Specifically, the burden of taking multiple medications has been associated with greater health care costs and an increased risk of adverse drug events (ADEs), drug-interactions, medication non-adherence, reduced functional capacity and
Adverse drug reactions (ADRs) are common in older adults , with falls, orthostatic hypotension, delirium, renal failure, gastrointestinal and intracranial bleeding being amongst the most common clinical manifestations.
Conducting medication reconciliations at care transition, eliminating duplicate medications, assessing for drug-drug interactions, and reviewing dosages can reduce the incidence of polypharmacy , ensure patient safety, reduce hospitalizations, and decrease associated costs.
Most commonly interacting drug combination was aspirin + enalapril (30.2%). Conclusion: A higher incidence of polypharmacy and increased risk of potential DDIs in elderly people with cardiovascular disease are major therapeutic issues at Yekatit 12 hospital.
Three of the most common tools used to manage polypharmacy are START, STOPP , and the Beer’s list.
The primary-care provider and specialists must maintain good communication with each other to prevent or minimize problems. Advise patients to use only one pharmacy to obtain medications; this adds another level of review to help ensure appropriate dosage and reduce the risk of adverse drugs effects and interactions.
Because the terms “excessive” and “unnecessary” are not easily quantifiable, the criteria often used in identifying polypharmacy are use of prescription medications that have no apparent indication, use of duplicate medications to treat the same disease or condition, concurrent use of interacting medications, use of an
Common geriatric syndromes include falls, cognitive impairment and delirium, depression, and polypharmacy ; these conditions are highly relevant for older adults with cancer. The presence of these conditions may influence overall ability to tolerate therapy as well as quality of life and potentially survival.
Epidemiological studies have found that the classes of drugs most commonly associated with adverse drug reactions in the elderly include diuretics, warfarin, non-steroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors, beta-blockers and angiotensin-converting enzyme (ACE)-inhibitors.
These physiological changes include increased body fat, decreased body water, decreased muscle mass, and changes in renal and liver function and in the Central Nervous System. These changes can cause adverse drug reactions (ADRs) in older people .