17, 2009 – The FDA today warned patients not to combine Plavix with Nexium , Prilosec , and nine other drugs — including Prozac and Tagamet . The drugs may make the anti-clotting drug Plavix dangerously less effective, the FDA says. They block an enzyme in the body that turns the drug into its active form.
Clopidogrel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: excessive tiredness. headache.
Common side effects of clopidogrel can include: headaches or dizziness. nausea . diarrhoea or constipation. indigestion (dyspepsia) stomach ache or abdominal pain . nosebleeds. increased bleeding (your blood taking longer to clot – for example, when you cut yourself), or easy bruising.
You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day . Most people prefer to take it in the morning , as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.
How long do I have to take Plavix ? Most experts recommend taking Plavix and aspirin for at least one year after getting a stent, unless the drug causes problems. If necessary, it can be stopped after three months with a bare-metal stent or six months with a drug-releasing stent.
Conclusions: Acute caffeine administration after clopidogrel loading appears to be associated with enhanced platelet inhibition 2 to 4 hours after clopidogrel intake. The mechanism probably involves synergistic increase in cAMP levels.
Cannabidiol inhibits CYP2C19, an isoenzyme responsible for the transformation of clopidogrel to its active thiol metabolite. This interaction could lead to subtherapeutic levels of active metabolite and possibly increased stroke risk.
Foods to avoid when taking heart medications Asparagus. Broccoli. Brussels sprouts . Cauliflower. Green onions. Kale. Parsley. Spinach.
There’s a risk that you could get a stomach ulcer. Is there any food or drink I need to avoid ? Do not drink grapefruit juice while taking clopidogrel . Grapefruit juice may increase the blood-thinning effect of your medicine.
The recommended dose is 75 mg per day for patient with a history of MI, stroke, or peripheral vascular disease. Many doctors may choose to add an aspirin per day along with the Plavix dose in both non-ST elevation and ST elevation MIs as well as to stroke and peripheral vascular disease patients.
Plavix is used to reduce the risk of heart attacks and strokes, particularly in people with a recent history of stroke or heart attack, and those with peripheral vascular disease. Plavix works by binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets.
Some patients have no side effects , have had very good results with Plavix and even credit it with saving their lives. Others have had many different side effects , bruising, uncontrollable bleeding, memory loss , fatigue, swelling of hands and feet and many more.
You may notice that you bruise or bleed more easily and it will take longer to stop bleeding while you are taking Plavix . This shows that Plavix is working . However, if bleeding is excessive, prolonged, or you notice blood in your urine or stool, seek urgent medical advice.
Plavix , alone or in combination with aspirin , can help lower this risk. When aspirin isn’t an option. If you are at high risk for a heart attack or stroke, but aspirin triggers an allergic reaction, doesn’t affect your platelets, or wreaks havoc with your stomach, Plavix may be a viable alternative.
Conclusions: Long term dual anti-platelet therapy with aspirin 81 mg daily and clopidogrel 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.