The first symptoms typically occur at 60–70 years of age.
|Progressive supranuclear palsy|
|Usual onset||60–70 years|
|Differential diagnosis||Parkinson’s disease, corticobasal degeneration, FTDP-17, Alzheimer’s disease|
|Treatment||Medication, physical therapy, occupational therapy|
The initial symptoms of PSP can include:
What causes PSP? PSP occurs when brain cells in certain parts of the brain are damaged as a result of a build-up of a protein called tau. Tau occurs naturally in the brain and is usually broken down before it reaches high levels. In people with PSP, it isn’t broken down properly and forms harmful clumps in brain cells.
Cerebral palsy and Parkinson’s are both neurological conditions that affect movement. However, cerebral palsy is caused by damage to the developing brain very early in life while Parkinson’s develops in late adulthood.
The final stages of PSP are usually dominated by an increasingly severe dysarthria and dysphagia. These features are usually described as being part of a pseudo-bulbar palsy, as brisk jaw and facial jerks may be present.
Progressive supranuclear palsy (PSP) is a condition that causes both dementia and problems with movement. It is a progressive condition that mainly affects people aged over 60. The word ‘supranuclear’ refers to the parts of the brain just above the nerve cells that control eye movement.
Although PSP isn’t fatal, symptoms do continue to worsen and it can’t be cured. Complications that result from worsening symptoms, such as pneumonia (from breathing in food particles while choking during eating), can be life threatening.
PSP and Parkinson’s PSP is often confused with Parkinson’s due to the similarity of symptoms, particularly stiffness, bradykinesia and movement difficulties. Both PSP and Parkinson’s cause parkinsonism – a combination of stiffness, slowness and clumsiness.
There are no known ways to reduce your risk of PSP.
Progressive supranuclear palsy (PSP) is usually sporadic (not inherited ), but in rare cases it can be inherited. While the genetic cause of PSP not usually known, it can be caused by a mutation in a gene called MAPT.
Drugs that are known to induce parkinsonism include:
Progressive supranuclear palsy (PSP) is a disease that mimics PD, particularly early in its course, but that comes with additional distinctive signs and symptoms. Individuals with PSP may fall frequently early in the course of disease.
Essential tremor (ET) is a neurological disorder that causes your hands, head, trunk, voice or legs to shake rhythmically. It is often confused with Parkinson’s disease. Essential tremor is the most common trembling disorder.
Although rare cases of PSP with more rapid progression have been described, they are typically over 2 to 3 years. Faster rates of a PSP phenotype suggest an alternative diagnosis, such as prion disease. We describe a patient whose course with pathologically confirmed PSP was under 2 years.
Many people living with PSP experience fatigue. Fatigue is an overwhelming feeling of tiredness, lack of energy and exhaustion. It is often referred to as an invisible symptom, and can be felt physically, emotionally and mentally.
It involves damage to many cells of the brain. Many areas are affected, including the part of the brainstem where cells that control eye movement are located. The area of the brain that controls steadiness when you walk is also affected. The frontal lobes of the brain are also affected, leading to personality changes.