Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as quetiapine have an increased risk of
Elderly patients should be started on SEROQUEL 50 mg/day and the dose can be increased in increments of 50 mg/day depending on the clinical response and tolerability of the individual patient. Patients with hepatic impairment should be started on 25 mg/day.
Extended -release tabs are not recommended for the elderly. Adverse reactions include dry mouth, dizziness, orthostatic hypotension, constipation, a feeling of sedation and more. There are a number of interactions with this drug.
Safety and effectiveness of Seroquel® and Seroquel XR® is supported by studies of Seroquel® for schizophrenia in adolescent patients 13 to 17 years of age and in bipolar mania in children and adolescent patients 10 to 17 years of age.
The risk of development of tardive dyskinesia is increased in nonschizophrenic elderly patients who are administered typical antipsychotics. Thus, because of the multitude of safety problems, typical antipsychotics are no longer recommended as first-line treatment for elderly patients with dementia.
Seroquel is not approved for the treatment of patients with dementia-related psychosis [see Warnings and Precautions (5.1)]. Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies.
Compared with placebo, the atypical antipsychotic drug quetiapine does not result in significant improvement in agitation in patients with dementia and is associated with a greater decline in cognitive function.
You should not use quetiapine if you are allergic to it. Quetiapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Quetiapine is not approved for use by anyone younger than 10 years old.
It’s best to start with the lowest dose possible. If there have been visual hallucinations or other signs of possible Lewy-Body dementia, quetiapine is usually the safest first choice.
Atypical antipsychotics (AAPs) are approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder.
Quetiapine can cause significant weight gain, even when used in small to moderate doses for sleep. It has also been associated with increased blood glucose (sugar) and dyslipidaemia (an imbalance of fats circulating in the blood). These increase the risk of developing type 2 diabetes and heart disease.
Constipation, drowsiness, upset stomach, tiredness, weight gain, blurred vision, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor promptly. Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug.
Who should not take SEROQUEL XR?
The experts’first-line recommendation for late-life schizophrenia was risperidone (1.25-3.5 mg/day). Quetiapine (100-300 mg/day), olanzapine (7.5-15 mg/day), and aripiprazole (15-30 mg/day) were high second line. For older patients with delusional disorder, an antipsychotic was the only treatment recommended.
Quetiapine is frequently used to treat psychosis in patients with Alzheimer’s disease (AD) and other dementias. These patients commonly have sleep disturbances that include nighttime awakenings with confused, agitated behaviors.
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