March 28, 2012 — The selective serotonin reuptake inhibitor (SSRI) citalopram ( Celexa , Forest Laboratories) should not be used at doses greater than 20 mg per day in adults older than 60 years because of a potential risk for QT prolongation, the FDA warns.
Tricyclic antidepressants , especially amitriptyline and dothiepin ,16 are known to pose a high risk of death in overdosage. These drugs should therefore be avoided in older people whose medication is not supervised and who are at risk of taking an overdose.
Another study published last year from researchers in Taiwan also linked SSRIs with an increased risk of dementia . However, a U.S. team reported two years ago the SSRI citalopram (sold under the brand name Celexa ) appeared to reduce production of the deadly brain plaques tied to Alzheimer’s.
The most commonly reported side effects were nausea , somnolence, dry mouth , increased sweating , tremor, diarrhea , and ejaculation disorder.
Buspirone is an anti-anxiety drug that has been shown to be effective for older adults. Benzodiazepines , another anti-anxiety drug, are effective but should be prescribed carefully to older adults because of risk of memory impairment, unsteadiness, and falls.
SSRIs considered to have the best safety profile in the elderly are citalopram , escitalopram , and sertraline .
New research links certain medications to dementia risk amitriptyline , paroxetine, and bupropion (most commonly taken for depression) oxybutynin and tolterodine (taken for an overactive bladder) diphenhydramine (a common antihistamine, as found in Benadryl ).
Diphenhydramine and amitriptiline are the most common inappropriately prescribed medications with high risk adverse events while propoxyphene and doxazoxin are the most commonly prescribed medications with low risk adverse events.
Many drugs that act on the brain can cause delirium, including narcotic painkillers, sedatives (particularly benzodiazepines), stimulants, sleeping pills, antidepressants , Parkinson’s disease medications, and antipsychotics.
Citalopram ( Celexa ) Medications And Detox Because this medication is an SSRI and adjusts the serotonin levels in the brain, patients wanting or needing to stop taking Citalopram ( Celexa ) should taper off the medication with the help of a doctor, instead of stopping suddenly or “going cold turkey ”.
Researchers developed the diet by looking at the Mediterranean and DASH diets, then focusing on the foods with the most compelling findings in dementia prevention. Vegetables , especially leafy greens , rose to the top. In general, fruit didn’t, though berries made the list.
Three cholinesterase inhibitors are commonly prescribed: Donepezil (marketed under the brand name Aricept ), which is approved to. treat all stages of Alzheimer’s disease. Galantamine ( Razadyne ), approved for mild-to-moderate stages. Rivastigmine (Exelon), approved for mild-to-moderate Alzheimer’s as well.
Celexa has been associated with slight weight gain , but it’s thought that the drug itself doesn’t cause this effect. Rather, the weight increase is likely due to improved appetite from taking the drug. A better appetite can cause you to eat more, leading to increased body weight .
Side effects such as tiredness, dry mouth and sweating are common. They’re usually mild and go away after a couple of weeks. If you and your doctor decide to take you off citalopram, your doctor may recommend reducing your dose gradually to help prevent extra side effects .
Missing doses of citalopram may increase your risk for relapse in your symptoms. Stopping citalopram abruptly may result in one or more of the following withdrawal symptoms: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).